GO:0008385 cellular_component IkappaB kinase complex
| PAG Title | GO:0008385 cellular_component IkappaB kinase complex |
| PAG ID | TAX017234 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. |
| Species | Homo sapiens |
| nCoCo Score | 897 |
| Base PAG ID | TAX017234 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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